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Article

The protective effect of delta-aminolevulinic acid dehydratase 1-2 and 2-2 isozymes against blood lead with higher hematologic parameters.

Environmental health perspectives - 1 Apr 2004

Kim Hee-Seon, Lee Sung-Soo, Lee Gap-Soo, Hwangbo Young, Ahn Kyu-Dong, Lee Byung-Kook

Abstract excerpt

Previous studies have suggested that delta-aminolevulinic acid dehydratase (ALAD) types 1-2 or 2-2 are protective against the toxicity of blood lead (PbB) when zinc protoporphyrin (ZPP) levels are low because of differential binding of lead in erythrocytes. The hypothesis is that subjects with the ALAD 1-1 genotype are more susceptible to lead exposure with impaired hematologic synthesis and therefore that iron...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15064157
DOI: 10.1289/ehp.6464
PMCID: PMC1241917

Genes

ALAD

Provenance

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The protective effect of delta-aminolevulinic acid dehydratase 1-2 and 2-2 isozymes against blood lead with higher hematologic parameters.PMID 15064157Read ↗

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Delta-aminolevulinic acid dehydratase genotype and lead toxicity: a HuGE review.Semantic proximity Read ↗

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