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Article

Solution structure of a phage-derived peptide antagonist in complex with vascular endothelial growth factor.

Journal of molecular biology - 22 Feb 2002

Pan Borlan, Li Bing, Russell Stephen J, Tom Jeffrey Y K, Cochran Andrea G, Fairbrother Wayne J

Abstract excerpt

Vascular endothelial growth factor (VEGF) is a potent endothelial cell-specific mediator of angiogenesis and vasculogenesis. VEGF is involved pathologically in cancer, proliferative retinopathy and rheumatoid arthritis, and as such represents an important therapeutic target. Three classes of disulfide-constrained peptides that antagonize binding of the VEGF dimer to its receptors, KDR and Flt-1, were identified...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11866530
DOI: 10.1006/jmbi.2001.5370

Genes

KDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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