Article
Solution structure of the tumor necrosis factor receptor-1 death domain.
Journal of molecular biology - 20 Jul 2001
Sukits S F, Lin L L, Hsu S, Malakian K, Powers R, Xu G Y
Abstract excerpt
Tumor necrosis factor receptor-1 death domain (TNFR-1 DD) is the intracellular functional domain responsible for the receptor signaling activities. The solution structure of the R347K mutant of TNFR-1 DD was solved by NMR spectroscopy. A total of 20 structures were calculated by means of hybrid distance geometry-simulated annealing using a total of 1167 distance constraints and 117 torsion angle constraints. The...
Topics
- Amino Acid Sequence
- Amino Acid Substitution
- Conserved Sequence
- Humans
- Hydrogen-Ion Concentration
- Models, Molecular
- Molecular Sequence Data
- Multigene Family
- Mutation
- Nuclear Magnetic Resonance, Biomolecular
- Protein Structure, Secondary
- Protein Structure, Tertiary
- Receptors, Tumor Necrosis Factor
- Solutions
- Static Electricity
- Structure-Activity Relationship