Article
Solution structure of the tumor necrosis factor receptor-1 death domain.
Journal of molecular biology - 20 Jul 2001
Sukits S F, Lin L L, Hsu S, Malakian K, Powers R, Xu G Y
Abstract excerpt
Tumor necrosis factor receptor-1 death domain (TNFR-1 DD) is the intracellular functional domain responsible for the receptor signaling activities. The solution structure of the R347K mutant of TNFR-1 DD was solved by NMR spectroscopy. A total of 20 structures were calculated by means of hybrid distance geometry-simulated annealing using a total of 1167 distance constraints and 117 torsion angle constraints. The...
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