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Article

The solution structure of the F42A mutant of human interleukin 2.

Journal of molecular biology - 14 Apr 1995

Mott H R, Baines B S, Hall R M, Cooke R M, Driscoll P C, Weir M P, Campbell I D

Abstract excerpt

Interleukin 2 (IL-2) is one of the major cytokines produced by T lymphocytes in response to antigen. It is a potent growth and differentiation factor for several cell-types and is structurally related to the four-helix bundle family of cytokines. Mutation of residue Phe42 to Ala abolishes binding to the alpha chain of the tri-partite IL-2 receptor. The three-dimensional structure of the F42A mutant IL-2 has been...

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Identifiers

PMID: 7723044
DOI: 10.1006/jmbi.1994.0194

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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