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Article

The solution structure of the F42A mutant of human interleukin 2.

Journal of molecular biology - 14 Apr 1995

Mott H R, Baines B S, Hall R M, Cooke R M, Driscoll P C, Weir M P, Campbell I D

Abstract excerpt

Interleukin 2 (IL-2) is one of the major cytokines produced by T lymphocytes in response to antigen. It is a potent growth and differentiation factor for several cell-types and is structurally related to the four-helix bundle family of cytokines. Mutation of residue Phe42 to Ala abolishes binding...

Topics

Alanine
Amino Acid Sequence
Computer Simulation
Crystallography, X-Ray
Humans
Hydrogen Bonding
Interleukin-2
Magnetic Resonance Spectroscopy
Models, Molecular
Molecular Sequence Data
Mutation
Phenylalanine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Conformation

Protein Structure, Secondary

Receptors, Interleukin-2

Recombinant Proteins

Solutions

Source

Identifiers

PMID: 7723044
DOI: 10.1006/jmbi.1994.0194

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7723044-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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