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Article

Biallelic deletions in INK4 in cutaneous melanoma are common and associated with decreased survival.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2005

Grafström Eva, Egyházi Suzanne, Ringborg Ulrik, Hansson Johan, Platz Anton

Abstract excerpt

PURPOSE: Both the retinoblastoma and p53 pathways are often genetically altered in human cancers and their complex regulation is in part mediated by the three gene products p16, p14(ARF), and p15 of the INK4 locus on chromosome 9p21. Partial or complete biallelic deletions of the INK4 locus have been recognized in a variety of malignant tumors, including malignant melanoma. We have in the present study measured...

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PMID: 15837753
DOI: 10.1158/1078-0432.CCR-04-1731

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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