Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between INK4a-ARF and p53 mutations in skin carcinomas of xeroderma pigmentosum patients.

Journal of the National Cancer Institute - 15 Nov 2000

Soufir N, Daya-Grosjean L, de La Salmonière P, Moles J P, Dubertret L, Sarasin A, Basset-Seguin N

Abstract excerpt

BACKGROUND: The INK4a-ARF locus encodes two tumor suppressor proteins, p16(INK4a) and p14(ARF), that act through the Rb-CDK4 and p53 pathways, respectively. Data from murine models and sporadic human skin carcinomas implicate p16(INK4a) and p14(ARF) in the development of skin carcinomas. We examined the frequency of INK4a-ARF, p53, and CDK4 mutations in skin carcinomas from patients with xeroderma pigmentosum...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Africa, Northern
Share to Carcinoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p16

Share to Cyclin-Dependent Kinases

Share to Genes, Tumor Suppressor

Share to Tumor Suppressor Protein p14ARF

Share to Ultraviolet Rays

Share to Xeroderma Pigmentosum

Source

Identifiers

PMID: 11078762
DOI: 10.1093/jnci/92.22.1841

Genes

CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between INK4a-ARF and p53 mutations in skin carcinomas of xeroderma pigmentosum patients.PMID 11078762Read ↗

[The INK4a-ARF locus: role in the genetic predisposition to familial melanoma and in skin carcinogenesis].Semantic proximity Read ↗

Genetic Alterations in the INK4a/ARF Locus: Effects on Melanoma Development and Progression.Semantic proximity Read ↗

The role of UV induced lesions in skin carcinogenesis: an overview of oncogene and tumor suppressor gene modifications in xeroderma pigmentosum skin tumors.Semantic proximity Read ↗

UVB-induced mutations in human key gatekeeper genes governing signalling pathways and consequences for skin tumourigenesis.Semantic proximity Read ↗

INK4/ARF germline alterations in pancreatic cancer patients.Semantic proximity Read ↗

Genomic instability, mutations and expression analysis of the tumour suppressor genes p14(ARF), p15(INK4b), p16(INK4a) and p53 in actinic keratosis.Semantic proximity Read ↗

Somatic INK4a-ARF locus mutations: a significant mechanism of gene inactivation in squamous cell carcinomas of the head and neck.Semantic proximity Read ↗

Alterations of INK4A and INK4B Genes in Adult Soft Tissue Sarcomas: Effect on SurvivalSemantic proximity Read ↗

Biallelic deletions in INK4 in cutaneous melanoma are common and associated with decreased survival.Semantic proximity Read ↗

Loss of CDKN2A and p14ARF expression occurs frequently in human nonmelanoma skin cancers.Semantic proximity Read ↗

High frequency of ultraviolet mutations at the INK4a-ARF locus in squamous cell carcinomas from psoralen-plus-ultraviolet-A-treated psoriasis patients.Semantic proximity Read ↗

P16 UV mutations in human skin epithelial tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.