Article
Genetic analysis of a clinical isolate of human cytomegalovirus exhibiting resistance against both ganciclovir and cidofovir.
Archives of virology - 1 Jan 1997
Harada K, Eizuru Y, Isashiki Y, Ihara S, Minamishima Y
Abstract excerpt
Both ganciclovir-sensitive and -resistant human cytomegaloviruses (HCMV) were isolated from a patient with aplastic anemia complicated with CMV retinitis and encephalitis. Ganciclovir-resistant clinical isolate, 93-1R, also showed cross-resistance against (s)-1-(3-hydroxy-2-phosphonylmethoxypropy...
Topics
- Antiviral Agents
- Cidofovir
- Cytomegalovirus
- Cytomegalovirus Infections
- Cytosine
- DNA, Viral
- Drug Resistance, Microbial
- Ganciclovir
- Humans
- Mutation
- Organophosphonates
- Organophosphorus Compounds
- Sequence Analysis, DNA