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Article

Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: potential links in endocrine development.

Molecular endocrinology (Baltimore, Md.) - 1 Oct 1996

Ikeda Y, Swain A, Weber T J, Hentges K E, Zanaria E, Lalli E, Tamai K T, Sassone-Corsi P, Lovell-Badge R, Camerino G, Parker K L

Abstract excerpt

Mutations of the orphan nuclear receptors, steroidogenic factor 1 (SF-1) and DAX-1, cause complex endocrine phenotypes that include impaired adrenal development and hypogonadotrophic hypogonadism. These similar phenotypes suggest that SF-1 and DAX-1 act in the same pathway(s) of endocrine development. To explore this model, we now compare directly their sites of expression. In mouse embryos, SF-1 expression in...

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PMID: 9121493
DOI: 10.1210/mend.10.10.9121493

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Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: potential links in endocrine development.PMID 9121493Read ↗

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