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Article

Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: potential links in endocrine development.

Molecular endocrinology (Baltimore, Md.) - 1 Oct 1996

Ikeda Y, Swain A, Weber T J, Hentges K E, Zanaria E, Lalli E, Tamai K T, Sassone-Corsi P, Lovell-Badge R, Camerino G, Parker K L

Abstract excerpt

Mutations of the orphan nuclear receptors, steroidogenic factor 1 (SF-1) and DAX-1, cause complex endocrine phenotypes that include impaired adrenal development and hypogonadotrophic hypogonadism. These similar phenotypes suggest that SF-1 and DAX-1 act in the same pathway(s) of endocrine develop...

Topics

Animals
Cell Lineage
DAX-1 Orphan Nuclear Receptor
DNA-Binding Proteins
Endocrine Glands
Female
Fushi Tarazu Transcription Factors
Gene Expression Regulation, Developmental
Homeodomain Proteins
In Situ Hybridization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mutation

Organ Specificity

Pregnancy

Receptors, Cytoplasmic and Nuclear

Receptors, Retinoic Acid

Repressor Proteins

Steroidogenic Factor 1

Source

Identifiers

PMID: 9121493
DOI: 10.1210/mend.10.10.9121493

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9121493-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: potential links in endocrine development.PMID 9121493Read ↗

Steroidogenic factor 1: an essential mediator of endocrine development.Semantic proximity Read ↗

Minireview: steroidogenic factor 1: its roles in differentiation, development, and disease.Semantic proximity Read ↗

The murine Dax-1 promoter is stimulated by SF-1 (steroidogenic factor-1) and inhibited by COUP-TF (chicken ovalbumin upstream promoter-transcription factor) via a composite nuclear receptor-regulatory element.Semantic proximity Read ↗

DAX-1, an Unusual Orphan Receptor at the Crossroads of Steroidogenic Function and Sexual DifferentiationSemantic proximity Read ↗

Dax-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1) gene transcription is regulated by wnt4 in the female developing gonad.Semantic proximity Read ↗

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Congenital adrenal hypoplasia and DAX-1 gene mutations.Semantic proximity Read ↗

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Excess DAX1 leads to XY ovotesticular disorder of sex development (DSD) in mice by inhibiting steroidogenic factor-1 (SF1) activation of the testis enhancer of SRY-box-9 (Sox9).Semantic proximity Read ↗

Hypogonadotropic hypogonadism in subjects with DAX1 mutations.Semantic proximity Read ↗

Role of DAX-1 (NR0B1) and steroidogenic factor-1 (NR5A1) in human adrenal function.Semantic proximity Read ↗

Phenotypic spectrum of mutations in DAX-1 and SF-1.Semantic proximity Read ↗

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