Article
Dax-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1) gene transcription is regulated by wnt4 in the female developing gonad.
Molecular endocrinology (Baltimore, Md.) - 1 Apr 2003
Mizusaki Hirofumi, Kawabe Ken, Mukai Tokuo, Ariyoshi Etsuko, Kasahara Megumi, Yoshioka Hidefumi, Swain Amanda, Morohashi Ken-Ichirou
Abstract excerpt
Dax-1 [dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (NR0B1)] is an orphan nuclear receptor acting as a suppressor of Ad4 binding protein/steroidogenic factor 1 [Ad4BP/SF-1 (NR5A1)] and as an anti-Sry factor in the process of gonadal sex differentiation. The roles of these nuclear receptors in the differentiation of the gonads and the adrenal cortex have...
Topics
- Amino Acids
- Animals
- Binding Sites
- Cells, Cultured
- Cytoskeletal Proteins
- DAX-1 Orphan Nuclear Receptor
- DNA-Binding Proteins
- Female
- Fushi Tarazu Transcription Factors