Article
Dax-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1) gene transcription is regulated by wnt4 in the female developing gonad.
Molecular endocrinology (Baltimore, Md.) - 1 Apr 2003
Mizusaki Hirofumi, Kawabe Ken, Mukai Tokuo, Ariyoshi Etsuko, Kasahara Megumi, Yoshioka Hidefumi, Swain Amanda, Morohashi Ken-Ichirou
Abstract excerpt
Dax-1 [dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (NR0B1)] is an orphan nuclear receptor acting as a suppressor of Ad4 binding protein/steroidogenic factor 1 [Ad4BP/SF-1 (NR5A1)] and as an anti-Sry factor in the process of gonadal sex differentiation. The roles of these nuclear receptors in the differentiation of the gonads and the adrenal cortex have...
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