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Article

DAX-1 (NR0B1) and steroidogenic factor-1 (SF-1, NR5A1) in human disease.

Best practice & research. Clinical endocrinology & metabolism - 1 Aug 2015

Suntharalingham Jenifer P, Buonocore Federica, Duncan Andrew J, Achermann John C

Abstract excerpt

DAX-1 (NR0B1) and SF-1 (NR5A1) are two nuclear receptor transcription factors that play a key role in human adrenal and reproductive development. Loss of DAX-1 function is classically associated with X-linked adrenal hypoplasia congenita. This condition typically affects boys and presents as primary adrenal insufficiency in early infancy or childhood, hypogonadotropic hypogonadism at puberty and impaired...

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Identifiers

PMID: 26303087
DOI: 10.1016/j.beem.2015.07.004
PMCID: PMC5159745

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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