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Article

ATM Mutations in Cancer: Therapeutic Implications.

Molecular cancer therapeutics - 1 Aug 2016

Choi Michael, Kipps Thomas, Kurzrock Razelle

Abstract excerpt

Activation of checkpoint arrest and homologous DNA repair are necessary for maintenance of genomic integrity during DNA replication. Germ-line mutations of the ataxia telangiectasia mutated (ATM) gene result in the well-characterized ataxia telangiectasia syndrome, which manifests with an increased cancer predisposition, including a 20% to 30% lifetime risk of lymphoid, gastric, breast, central nervous system,...

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Source

Identifiers

PMID: 27413114
DOI: 10.1158/1535-7163.MCT-15-0945

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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