Article
Splitting the ATM: distinct repair and checkpoint defects in ataxia-telangiectasia.
Trends in genetics : TIG - 1 Aug 1998
Jeggo P A, Carr A M, Lehmann A R
Abstract excerpt
Ataxia-telangiectasia (A-T) is an autosomal recessive human disorder that, because of its multisystem nature, is of interest to scientists and clinicians from many disciplines. A-T patients have defects in the neurological and immune systems, telangiectasia in the eyes and face, and are, in addit...
Topics
- Animals
- Ataxia Telangiectasia
- Ataxia Telangiectasia Mutated Proteins
- Cell Cycle Proteins
- DNA Repair
- DNA-Binding Proteins
- Humans
- Mice
- Mice, Knockout
- Mice, SCID
- Mutation
- Neoplasms
- Phenotype