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Article

Loss of p53 transcriptional activity in hepatocellular carcinoma evaluated by yeast-based functional assay: comparison with p53 immunohistochemistry.

Human pathology - 1 Mar 2004

Mitsumoto Yasuhide, Nakajima Tomoki, Marutani Masumi, Kashiwazaki Haruhiko, Moriguchi Michihisa, Kimura Hiroyuki, Okanoue Takeshi, Kagawa Keizo, Tada Mitsuhiro

Abstract excerpt

We studied the transcriptional activity of p53 protein in 50 tissues of hepatocellular carcinoma (HCC) using a yeast functional assay. In this assay, red yeast colonies indicate that p53 protein cannot bind to its specific domain and has lost its transcriptional activity. We also clarified whether mutant p53 protein could inactivate wild-type p53 protein in a transdominant manner using a modified yeast assay. In...

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p53

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Share to Liver Neoplasms

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Source

Identifiers

PMID: 15017592
DOI: 10.1016/j.humpath.2003.09.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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