Article
Design of bioelectronic interfaces by exploiting hinge-bending motions in proteins.
Science (New York, N.Y.) - 31 Aug 2001
Benson D E, Conrad D W, de Lorimier R M, Trammell S A, Hellinga H W
Abstract excerpt
We report a flexible strategy for transducing ligand-binding events into electrochemical responses for a wide variety of proteins. The method exploits ligand-mediated hinge-bending motions, intrinsic to the bacterial periplasmic binding protein superfamily, to establish allosterically controlled...
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