Article
Mutagenic and epigenetic effects of DNA methylation.
Mutation research - 1 Apr 1997
Gonzalgo M L, Jones P A
Abstract excerpt
Tumorigenesis begins with the disregulated growth of an abnormal cell that has acquired the ability to divide more rapidly than its normal counterparts (Nowell, P.C. (1976) Science, 194, 23-28 [1]). Alterations in global levels and regional changes in the patterns of DNA methylation are among the earliest and most frequent events known to occur in human cancers (Feinberg and Vogelstein (1983) Nature, 301, 89-92...
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