DNA methylation and the association between genetic and epigenetic changes: relation to carcinogenesis.

doi:10.1016/s0027-5107(97)00003-1

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Article

DNA methylation and the association between genetic and epigenetic changes: relation to carcinogenesis.

Mutation research - 14 Apr 1997

Wachsman J T

Abstract excerpt

This paper examines the relationship between DNA mutagenic lesions, DNA methylation and the involvement of these changes in the process of carcinogenesis. Many types of DNA damage (oxidative lesions, alkylation of bases, abasic sites, photodimers, etc.) interfere with the ability of mammalian cel...

Topics

5-Methylcytosine
Alkylating Agents
Animals
Cytosine
DNA Damage
DNA Methylation
DNA Modification Methylases
DNA Repair
Enzyme Inhibitors
Humans
Mutation
Neoplasms
Nucleic Acid Synthesis Inhibitors
Oxidative Stress
Topoisomerase II Inhibitors

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