Genetic alterations and DNA repair in human carcinogenesis.

Abstract excerpt

A causal association between genetic alterations and cancer is supported by extensive experimental and epidemiological data. Mutational inactivation of tumor suppressor genes and activation of oncogenes are associated with the development of a wide range of cancers. The link between mutagenesis and carcinogenesis is particularly evident for cancers induced by chemical exposures, which, in some cases, lead to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Transformation, Neoplastic
• Share to DNA Repair
• Share to Gene Expression Regulation, Neoplastic