Article
Oxidative stress, DNA methylation and carcinogenesis.
Cancer letters - 18 Jul 2008
Franco Rodrigo, Schoneveld Onard, Georgakilas Alexandros G, Panayiotidis Mihalis I
Abstract excerpt
Transformation of a normal cell to a malignant one requires phenotypic changes often associated with each of the initiation, promotion and progression phases of the carcinogenic process. Genes in each of these phases acquire alterations in their transcriptional activity that are associated either with hypermethylation-induced transcriptional repression (in the case of tumor suppressor genes) or...
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