Article
Complete analysis of the presenilin 1 gene in early onset Alzheimer's disease.
Neuroreport - 29 Feb 1996
Hutton M, Busfield F, Wragg M, Crook R, Perez-Tur J, Clark R F, Prihar G, Talbot C, Phillips H, Wright K, Baker M, Lendon C, Duff K, Martinez A, Houlden H, Nichols A, Karran E, Roberts G, Roques P, Rossor M, Venter J C, Adams M D, Cline R T, Phillips C A, Goate A
Abstract excerpt
The presenilin 1 gene has recently been identified as the locus on chromosome 14 which is responsible for a large proportion of early onset, autosomal dominantly inherited Alzheimer's disease (AD). We have elucidated the intron/exon structure of the gene and designed intronic primers to enable direct sequencing of the entire coding region (10 exons) of the presenilin gene in a large number of families. This...
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