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Article

Thrombomodulin changes the molecular surface of interaction and the rate of complex formation between thrombin and protein C.

The Journal of biological chemistry - 4 Mar 2005

Xu Hong, Bush Leslie A, Pineda Agustin O, Caccia Sonia, Di Cera Enrico

Abstract excerpt

The interaction of thrombin with protein C triggers a key down-regulatory process of the coagulation cascade. Using a panel of 77 Ala mutants, we have mapped the epitope of thrombin recognizing protein C in the absence or presence of the cofactor thrombomodulin. Residues around the Na(+) site (Thr-172, Lys-224, Tyr-225, and Gly-226), the aryl binding site (Tyr-60a), the primary specificity pocket (Asp-189), and...

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Identifiers

PMID: 15582990
DOI: 10.1074/jbc.M412869200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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