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Article

Transcription of the Trypanosoma brucei spliced leader RNA gene is dependent only on the presence of upstream regulatory elements.

Molecular and biochemical parasitology - 1 Mar 1997

Günzl A, Ullu E, Dörner M, Fragoso S P, Hoffmann K F, Milner J D, Morita Y, Nguu E K, Vanacova S, Wünsch S, Dare A O, Kwon H, Tschudi C

Abstract excerpt

The spliced leader (SL) RNA plays a key role in mRNA maturation in trypanosomatid protozoa by providing the SL sequence, which is joined to the 5' end of every mRNA. As a first step towards a better understanding of the biogenesis and function of the SL RNA, we expressed a tagged SL RNA gene in a cell-free system of procyclic Trypanosoma brucei cells. Transcription initiates at + 1 can be detected as early as 1...

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PMID: 9108549
DOI: 10.1016/s0166-6851(96)02816-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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