Article
The trypanosomatid signal recognition particle consists of two RNA molecules, a 7SL RNA homologue and a novel tRNA-like molecule.
The Journal of biological chemistry - 16 May 2003
Liu Li, Ben-Shlomo Herzel, Xu Yu-Xin, Stern Michael Zeev, Goncharov Igor, Zhang Yafei, Michaeli Shulamit
Abstract excerpt
Trypanosomatids are ancient eukaryotic parasites affecting humans and livestock. Here we report that the trypanosomatid signal recognition particle (SRP), unlike all other known SRPs in nature, contains, in addition to the 7SL RNA homologue, a short RNA molecule, termed sRNA-85. Using conventional chromatography, we discovered a small RNA molecule of 85 nucleotides co-migrating with the Leptomonas collosoma 7SL...
Topics
- Animals
- Base Sequence
- Biotinylation
- Chromatography
- Cloning, Molecular
- Cross-Linking Reagents
- In Situ Hybridization
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Oligonucleotides, Antisense
- Plasmids
- Protein Structure, Tertiary