Article
Differential RNA elongation controls the variant surface glycoprotein gene expression sites of Trypanosoma brucei.
Molecular microbiology - 1 Apr 2000
Vanhamme L, Poelvoorde P, Pays A, Tebabi P, Van Xong H, Pays E
Abstract excerpt
The protozoan parasite Trypanosoma brucei develops antigenic variation to escape the immune response of its host. To this end, the trypanosome genome contains multiple telomeric expression sites competent for transcription of variant surface glycoprotein genes, but as a rule only a single antigen is expressed at any time. We used reverse transcription-PCR (RT-PCR) to analyse transcription of different segments of...
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