Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spliced Leader Trapping Reveals Widespread Alternative Splicing Patterns in the Highly Dynamic Transcriptome of Trypanosoma brucei

5 Aug 2010

Abstract excerpt

Trans-splicing of leader sequences onto the 5'ends of mRNAs is a widespread phenomenon in protozoa, nematodes and some chordates. Using parallel sequencing we have developed a method to simultaneously map 5'splice sites and analyze the corresponding gene expression profile, that we term spliced leader trapping (SLT). The method can be applied to any organism with a sequenced genome and trans-splicing of a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathy and Myosin Studies
Share to Signaling Pathways in Disease
Share to Trypanosoma species research and implications

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20700444
DOI: 10.1371/journal.ppat.1001037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spliced Leader Trapping Reveals Widespread Alternative Splicing Patterns in the Highly Dynamic Transcriptome of Trypanosoma bruceiPMID 20700444Read ↗

Multiplexed Spliced-Leader Sequencing: A high-throughput, selective method for RNA-seq in TrypanosomatidsSemantic proximity Read ↗

<i>Trans</i> -Splicing in Trypanosomes: Machinery and Its Impact on the Parasite TranscriptomeSemantic proximity Read ↗

Comprehensive mRNA annotation in trypanosomatid parasitesSemantic proximity Read ↗

Gene expression in Trypanosoma brucei: lessons from high-throughput RNA sequencingSemantic proximity Read ↗

Comprehensive analysis of the Kinetoplastea intron landscape reveals a novel intron-containing gene and the first exclusively trans-splicing eukaryoteSemantic proximity Read ↗

The Transcriptome of the Human Pathogen Trypanosoma brucei at Single-Nucleotide ResolutionSemantic proximity Read ↗

The Pre-mRNA Splicing Machinery of Trypanosomes: Complex or Simplified?Semantic proximity Read ↗

A directed approach for the identification of transcripts harbouring the spliced leader sequence and the effect of trans-splicing knockdown in Schistosoma mansoni.Semantic proximity Read ↗

Widespread variation in transcript abundance within and across developmental stages of Trypanosoma bruceiSemantic proximity Read ↗

Trypanosomal TBP Functions with the Multisubunit Transcription Factor tSNAP To Direct Spliced-Leader RNA Gene ExpressionSemantic proximity Read ↗

Spliced Leader RNA Gene Transcription in Trypanosoma brucei Requires Transcription Factor TFIIHSemantic proximity Read ↗

Diversity and evolution of spliceosomal systems.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.