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Article

ALL-1 gene at chromosome 11q23 is consistently altered in acute leukemia of early infancy

15 Jul 1993

Abstract excerpt

Early infancy (< 1 year of age), massive tumor cell burden, and extremely poor prognosis are characteristic features of a particular subset of childhood acute leukemias (AL). In these cases, chromosome aberrations at the 11q23 band are the most frequently reported cytogenetic abnormalities. We have recently cloned a genetic locus named ALL-1, in which DNA breakpoints are clustered in leukemic patients with 11q23...

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Identifiers

PMID: 8329709
DOI: 10.1182/blood.v82.2.544.bloodjournal822544

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ALL-1 gene at chromosome 11q23 is consistently altered in acute leukemia of early infancyPMID 8329709Read ↗

Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcomeSemantic proximity Read ↗

Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcomeSemantic proximity Read ↗

Exon/intron structure of the human ALL‐1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemiasSemantic proximity Read ↗

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Complex variant t(4;11) characterized by fluorescence in situ hybridization in infant acute lymphoblastic leukemia.Semantic proximity Read ↗

Acute lymphoblastic leukemias with deletion of 11q23 or a novel inversion (11)(p13q23) lack MLL gene rearrangements and have favorable clinical featuresSemantic proximity Read ↗

DNA copy-number abnormalities do not occur in infant ALL with t(4;11)/MLL-AF4.Semantic proximity Read ↗

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