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Article

ALL-1 gene rearrangements in DNA topoisomerase II inhibitor-related leukemia in children

1 Jun 1995

Abstract excerpt

We examined clinical, morphologic, and cytogenetic features and ALL-1 (MLL, Htrxl, HRX) gene rearrangements in 17 cases of secondary leukemia that occurred 11 months to 9 years from diagnoses of primary cancers in children who received topoisomerase II inhibitors or developed secondary leukemias typical of those associated with this therapy. Primary diagnoses included nine solid tumors and eight leukemias. Ten...

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PMID: 7756657
DOI: 10.1182/blood.v85.11.3250.bloodjournal85113250

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