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B Cell Antigen Receptor Signaling: Roles in Cell Development and Disease

31 May 2002

Abstract excerpt

Signals propagated through the B cell antigen receptor (BCR) are vital for the development and survival of B lymphocytes in both the bone marrow and the periphery. These signals not only guide maturation and activation but also affect the removal of potentially self-reactive B lymphocytes. Interestingly, these signals are known to be either ligand-independent ("tonic" signals) or induced by ligand (antigen)...

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PMID: 12040177
DOI: 10.1126/science.1071546

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