[Stability of human immunodeficiency virus to azidothymidine. II. Kinetic characteristics of "AZT-resistant" mutant forms of reverse transcriptase].

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Article

[Stability of human immunodeficiency virus to azidothymidine. II. Kinetic characteristics of "AZT-resistant" mutant forms of reverse transcriptase].

Biokhimiia (Moscow, Russia) - 1 Jan 1996

Pokholok D K, Gudima S O, Memelova L V, Esipov D S, Rechinskiĭ V O, Kochetkov S N

Abstract excerpt

Prolonged treatment of AIDS patients with azidothymidine results in the development of resistance to the drug which correlates with the appearance of point mutations in the reverse transcriptase (RT) coding region within the HIV-1 pol gene. Kinetic studies of interactions of wild type RT and its...

Topics

Drug Resistance, Microbial
Genes, pol
HIV Reverse Transcriptase
HIV-1
Kinetics
Mutation
RNA-Directed DNA Polymerase
Substrate Specificity
Templates, Genetic
Zidovudine

Source

Open in PubMed

Identifiers

PMID: 8679772

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8679772-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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