Article
Retention of marked sensitivity to (S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4-di hydroquin oxaline-2(1H)-thione (HBY 097) by an azidothymidine (AZT)-resistant human immunodeficiency virus type 1 (HIV-1) strain subcultured in the combined presence of quinoxaline HBY 097 and 2',3'-dideoxy-3'-thiacytidine (lamivudine).
Biochemical pharmacology - 1 Mar 1998
Balzarini J, Pelemans H, Riess G, Roesner M, Winkler I, De Clercq E, Kleim J P
Abstract excerpt
An azidothymidine (AZT)-resistant virus strain (HIV-1/AZT) (containing the 67 Asp --> Asn, 70 Lys --> Arg, 215 Thr --> Phe and 219 Lys --> Gln mutations into its reverse transcriptase) was grown in the combined presence of 2',3'-dideoxy-3'-thiacytidine (3TC, lamivudine) and the nonnucleoside reve...
Topics
- Anti-HIV Agents
- Antiviral Agents
- Benzodiazepines
- Cell Line
- Delavirdine
- Drug Resistance, Microbial
- Furans
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Imidazoles
- Lamivudine
- Microbial Sensitivity Tests