Effect of modification of the beta-hairpin and long loops simultaneously in both alpha- and beta-subunits on the function of human choriogonadotropin: part II.

Abstract excerpt

According to the X-ray diffraction, human choriogonadotropin has four beta-hairpin and two long loops, equally distributed in each of the alpha and beta subunits. Radical mutations such as the replacement of alpha 18Phe and alpha 74Phe with Thr in the alpha1 and alpha3 loops respectively and the replacement of alpha 45Lys with Asp in the alpha2 loop in the alpha-subunit were introduced while the loop sequences in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Line
• Share to Cyclic AMP
• Share to Hydrogen-Ion Concentration