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Article

A Transforming Growth Factor β (TGFβ) Control Element Drives TGFβ-induced Stimulation of Smooth Muscle α-Actin Gene Expression in Concert with Two CArG Elements

1 Apr 1997

Abstract excerpt

The goal of the present study was to determine the molecular mechanism whereby transforming growth factor beta (TGFbeta) increases smooth muscle (SM) alpha-actin expression. Confluent, growth-arrested rat aortic smooth muscle cells (SMC) were transiently transfected with various SM alpha-actin promoter/chloramphenicol acetyltransferase deletion mutants and stimulated with TGFbeta (2.5 ng/ml). Results demonstrated...

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Identifiers

PMID: 9099754
DOI: 10.1074/jbc.272.16.10948

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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A Transforming Growth Factor β (TGFβ) Control Element Drives TGFβ-induced Stimulation of Smooth Muscle α-Actin Gene Expression in Concert with Two CArG ElementsPMID 9099754Read ↗

Nuclear factor of activated T cells and serum response factor cooperatively regulate the activity of an alpha-actin intronic enhancer.Semantic proximity Read ↗

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Smooth muscle cells and myofibroblasts use distinct transcriptional mechanisms for smooth muscle alpha-actin expression.Semantic proximity Read ↗

Transforming growth factor-beta induction of smooth muscle cell phenotpye requires transcriptional and post-transcriptional control of serum response factor.Semantic proximity Read ↗

Myocardin-dependent Activation of the CArG Box-rich Smooth Muscle γ-Actin GeneSemantic proximity Read ↗

A transforming growth factor-beta control element required for SM alpha-actin expression in vivo also partially mediates GKLF-dependent transcriptional repression.Semantic proximity Read ↗

Smooth muscle cell-specific transcription is regulated by nuclear localization of the myocardin-related transcription factors.Semantic proximity Read ↗

Myocardin: a component of a molecular switch for smooth muscle differentiation.Semantic proximity Read ↗

Myocardin is a key regulator of CArG-dependent transcription of multiple smooth muscle marker genes.Semantic proximity Read ↗

Smooth muscle alpha-actin gene requires two E-boxes for proper expression in vivo and is a target of class I basic helix-loop-helix proteins.Semantic proximity Read ↗

Two proximal CArG elements regulate SM alpha-actin promoter, a genetic marker of activated phenotype of mesangial cells.Semantic proximity Read ↗

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