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Article

Transforming growth factor-beta induction of smooth muscle cell phenotpye requires transcriptional and post-transcriptional control of serum response factor.

The Journal of biological chemistry - 22 Feb 2002

Hirschi Karen K, Lai Lihua, Belaguli Narasimhaswamy S, Dean David A, Schwartz Robert J, Zimmer Warren E

Abstract excerpt

Transforming growth factor-beta induces a smooth muscle cell phenotype in undifferentiated mesenchymal cells. To elucidate the mechanism(s) of this phenotypic induction, we focused on the molecular regulation of smooth muscle-gamma-actin, whose expression is induced at late stages of smooth muscle differentiation and developmentally restricted to this lineage. Transforming growth factor-beta induced smooth...

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Identifiers

PMID: 11741973
DOI: 10.1074/jbc.M106649200
PMCID: PMC4421896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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