Myocardin Enhances Smad3-Mediated Transforming Growth Factor-β ₁ Signaling in a CArG Box-Independent Manner

Abstract excerpt

Transforming growth factor (TGF)-beta1 is an important cytokine involved in various diseases. However, the molecular mechanism whereby TGF-beta1 signaling modulates the regulatory network for smooth muscle gene transcription remains largely unknown. To address this question, we previously identified a Smad-binding element (SBE) in the SM22alpha promoter as one of the TGF-beta1 response elements. Here, we show...

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