Article
Establishment and characterization of cloned CD4- CD8- alphabeta-T cell receptor (TCR)-bearing autoreactive T cells from autoimmune NZB x NZW F1 mice.
Clinical and experimental immunology - 1 Apr 1997
Chen Y C, Ye Y L, Chiang B L
Abstract excerpt
Murine models such as NZB/W F1, NZB.H-2bm12 and MRL.lpr/lpr mice have provided greater insight into the pathogenic mechanisms of lupus. To understand further the roles of T cells and cytokines in the pathogenesis of murine lupus, 11 cloned anti-DNA antibodies augmenting autoreactive T cell lines...
Topics
- Animals
- Antibodies
- Autoimmunity
- CD4 Antigens
- CD8 Antigens
- Clone Cells
- Cytokines
- Female
- Histocompatibility Antigens Class II
- Lupus Vulgaris
- Male
- Mice
- Phenotype
- Receptors, Antigen, T-Cell, alpha-beta
- Receptors, Interleukin-2
- T-Lymphocytes