Article
T cell receptor V beta genes expressed by IgG anti-DNA autoantibody-inducing T cells in lupus nephritis: forbidden receptors and double-negative T cells.
European journal of immunology - 1 Jul 1990
Adams S, Zordan T, Sainis K, Datta S
Abstract excerpt
In the (SWR x NZB)F1 (SNF1) model of lupus nephritis, pathogenic variety of IgG anti-DNA autoantibodies are induced by certain T helper (Th) cells that are either CD4+ or CD4-CD8- (double negative; DN) in phenotype. From the spleens of eight SNF1 mice with lupus nephritis, 149 T cell lines were d...
Topics
- Animals
- Antibodies, Antinuclear
- Cell Line
- Disease Models, Animal
- Genetic Complementation Test
- Immunoglobulin G
- Lupus Nephritis
- Lymphocyte Activation
- Mice
- Mice, Inbred C57BL
- Mice, Inbred NZB
- Phenotype
- Receptors, Antigen, T-Cell
- Receptors, Antigen, T-Cell, alpha-beta
- Spleen
- T-Lymphocytes