Article
Distinct surface phenotypes of B cells responsible for spontaneous production of IgM and IgG anti-DNA antibodies in autoimmune-prone NZB x NZW F1 mice.
Autoimmunity - 1 Jan 1990
Okada T, Abe M, Takiura F, Hirose S, Shirai T
Abstract excerpt
Autoimmune-prone NZB x NZW F1 (B/W F1) mice produce a high titer of anti-DNA antibodies, In vivo and in vitro studies showed that in the early life of these mice, the immunoglobulin isotype of these antibodies almost exclusively belongs to IgM class, however, IgG anti-DNA antibodies begin to deve...
Topics
- Aging
- Animals
- Antibodies, Antinuclear
- Antigens, Differentiation, B-Lymphocyte
- Autoimmune Diseases
- B-Lymphocyte Subsets
- Crosses, Genetic
- Disease Susceptibility
- Genetic Predisposition to Disease
- Immunoglobulin G
- Immunoglobulin M
- Lupus Erythematosus, Systemic
- Mice
- Mice, Inbred NZB
- Mice, Inbred Strains