Article
Distinct surface phenotypes of B cells responsible for spontaneous production of IgM and IgG anti-DNA antibodies in autoimmune-prone NZB x NZW F1 mice.
Autoimmunity - 1 Jan 1990
Okada T, Abe M, Takiura F, Hirose S, Shirai T
Abstract excerpt
Autoimmune-prone NZB x NZW F1 (B/W F1) mice produce a high titer of anti-DNA antibodies, In vivo and in vitro studies showed that in the early life of these mice, the immunoglobulin isotype of these antibodies almost exclusively belongs to IgM class, however, IgG anti-DNA antibodies begin to develop when the mice are about 5-6 months old and the titer exceeds that of IgM antibodies from age 7 months on. We asked...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.