Article
Target gene modulation in hepatocellular carcinomas by decreased DNA-binding of p53 mutations.
Hepatology (Baltimore, Md.) - 1 Apr 1997
Kubicka S, Trautwein C, Niehof M, Manns M
Abstract excerpt
The crystallographic structure of the p53 core domain showed that most of the p53 mutations found in human tumors are located in conserved regions of the p53 DNA-binding domain. The aim of our study was to investigate the effect on DNA-binding and transactivation of three p53 mutations frequently found in hepatocellular carcinomas (HCC). Two of these mutations are located near the DNA-binding surface and are...
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