Article
Target gene modulation in hepatocellular carcinomas by decreased DNA-binding of p53 mutations.
Hepatology (Baltimore, Md.) - 1 Apr 1997
Kubicka S, Trautwein C, Niehof M, Manns M
Abstract excerpt
The crystallographic structure of the p53 core domain showed that most of the p53 mutations found in human tumors are located in conserved regions of the p53 DNA-binding domain. The aim of our study was to investigate the effect on DNA-binding and transactivation of three p53 mutations frequently...
Topics
- Base Sequence
- Binding Sites
- Carcinoma, Hepatocellular
- DNA Primers
- DNA, Neoplasm
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Humans
- Liver Neoplasms
- Molecular Structure
- Mutagenesis, Site-Directed
- Mutation
- Protein Binding
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53