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Epidermal growth factor receptor

22 Sept 2012

Abstract excerpt

PURPOSE OF REVIEW: Amplification and overexpression of the epidermal growth factor receptor (EGFR) gene are a hallmark of primary glioblastoma (45%), making it a prime target for therapy. In addition, these amplifications are frequently associated with oncogenic mutations in the extracellular domain. However, efforts at targeting the EGFR tyrosine kinase using small molecule inhibitors or antibodies have shown...

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PMID: 23007009
DOI: 10.1097/wco.0b013e328359b0bc

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