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Article

Association of TNFAIP3 and TNFRSF1A variation with multiple sclerosis in a German case-control cohort.

International journal of immunogenetics - 1 Apr 2015

Hoffjan S, Okur A, Epplen J T, Wieczorek S, Chan A, Akkad D A

Abstract excerpt

Variations in two genes of the tumour necrosis factor (TNF) alpha pathway have been implicated in the pathogenesis of autoimmune diseases: polymorphisms in the TNFRSF1A gene, encoding TNF receptor 1, showed significant association with MS in genomewide association scans, and variation in or near the TNFAIP3 gene, coding for a negative regulator of NFkB, was associated with MS, systemic lupus erythematosus,...

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Source

Identifiers

PMID: 25684197
DOI: 10.1111/iji.12183

Genes

TNFAIP3
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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