Article
A human leptin mutant induces weight gain in normal mice.
FEBS letters - 24 Mar 1997
Verploegen S A, Plaetinck G, Devos R, Van der Heyden J, Guisez Y
Abstract excerpt
Leptin, a fat secreted hormone, regulates ingestive behaviour and energy balance by binding to a specific receptor. Using site-directed mutagenesis, we screened for single amino acid residues in human leptin which are critical for receptor binding and biological activity. Here we report that one of these mutants has in vivo antagonistic properties. An Arg to Gln substitution at position 128 of human leptin does...
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