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Article

Leptin Receptor Compound Heterozygosity in Humans and Animal Models.

International journal of molecular sciences - 25 Apr 2021

Berger Claudia, Klöting Nora

Abstract excerpt

Leptin and its receptor are essential for regulating food intake, energy expenditure, glucose homeostasis and fertility. Mutations within leptin or the leptin receptor cause early-onset obesity and hyperphagia, as described in human and animal models. The effect of both heterozygous and homozygous variants is much more investigated than compound heterozygous ones. Recently, we discovered a spontaneous compound...

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Identifiers

PMID: 33922961
DOI: 10.3390/ijms22094475
PMCID: PMC8123313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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