Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ENU mutagenesis identifies mice with morbid obesity and severe hyperinsulinemia caused by a novel mutation in leptin.

PloS one - 9 Dec 2010

Hong Chen-Jee, Tsai Pei-Jane, Cheng Chih-Ya, Chou Chuan-Kai, Jheng Huei-Fen, Chuang You-Chung, Yang Chia-Ning, Lin Ya-Tzu, Hsu Chih-Wei, Cheng Irene H, Chen Shiow-Yi, Tsai Shih-Jen, Liou Ying-Jay, Tsai Yau-Sheng

Abstract excerpt

BACKGROUND: Obesity is a multifactorial disease that arises from complex interactions between genetic predisposition and environmental factors. Leptin is central to the regulation of energy metabolism and control of body weight in mammals. METHODOLOGY/PRINCIPAL FINDINGS: To better recapitulate th...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Weight
Share to Ethylnitrosourea

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homozygote

Share to Hyperinsulinism

Share to Leptin

Share to Mutagenesis

Share to Obesity, Morbid

Share to Receptors, Leptin

Source

Open in PubMed Open full text

Identifiers

PMID: 21151569
DOI: 10.1371/journal.pone.0015333
PMCID: PMC3000341

Genes

NPY
SOCS1
SOCS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21151569-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ENU mutagenesis identifies mice with morbid obesity and severe hyperinsulinemia caused by a novel mutation in leptin.PMID 21151569Read ↗

Identification of mutations through dominant screening for obesity using C57BL/6 substrains.Semantic proximity Read ↗

Genetics of obesity in humans.Semantic proximity Read ↗

Animal models of obesitySemantic proximity Read ↗

The leptin melanocortin pathway and the control of body weight: lessons from human and murine geneticsSemantic proximity Read ↗

The 14th Ile residue is essential for Leptin function in regulating energy homeostasis in rat.Semantic proximity Read ↗

Adipocyte Long-Noncoding RNA Transcriptome Analysis of Obese Mice Identified Lnc-Leptin, Which Regulates LeptinSemantic proximity Read ↗

A Leptin Analog Locally Produced in the Brain Acts via a Conserved Neural Circuit to Modulate Obesity-Linked Behaviors in Drosophila.Semantic proximity Read ↗

Leptin gene-targeted editing in ob/ob mouse adipose tissue based on the CRISPR/Cas9 systemSemantic proximity Read ↗

Characterization of a novel genetically obese mouse model demonstrating early onset hyperphagia and hyperleptinemia.Semantic proximity Read ↗

Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity.Semantic proximity Read ↗

Obese locus in WNIN/obese rat maps on chromosome 5 upstream of leptin receptor.Semantic proximity Read ↗

N-ethyl-N-nitrosourea-based generation of mouse models for mutant G protein-coupled receptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.