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Article

Functional characterization and pharmacological rescue of melanocortin-4 receptor mutations identified from obese patients.

Journal of cellular and molecular medicine - 1 Sept 2009

Fan Zhen-Chuan, Tao Ya-Xiong

Abstract excerpt

As the most common monogenic form of human obesity, about 130 naturally occurring melanocortin-4 receptor (MC4R) gene mutations have been identified. In this study, we reported detailed functional characterization of 10 novel human MC4R (hMC4R) mutants including R7C, C84R, S127L, S136F, W174C, A219V, P230L, F261S, I317V and L325F. Flow cytometry experiments showed that six mutants, including R7C, C84R, S127L,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Melanocortin, Type 4

Source

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Identifiers

PMID: 19298524
DOI: 10.1111/j.1582-4934.2009.00726.x
PMCID: PMC4516484

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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