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Article

DRB4 promoter polymorphism in DR7 individuals: correlation with DRB4 pre-mRNA and mRNA levels.

Immunogenetics - 1 Jan 1997

Leën M P, Gorski J

Abstract excerpt

DRB genes encode proteins which play an important role in the immune response, and variation in their expression levels may be of functional immunological significance. To date, HLA class II gene promoter polymorphism has been analyzed almost exclusively in Epstein-Barr virus (EBV)-transformed B-cell lines. While previous studies have established important paradigms with regard to the mechanisms in DRB gene...

Topics

Alleles
Base Sequence
Gene Expression Regulation
HLA-DR Antigens
HLA-DR7 Antigen
HLA-DRB4 Chains
Humans
Molecular Sequence Data
Polymorphism, Genetic
Promoter Regions, Genetic
RNA Precursors

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Identifiers

PMID: 9089094
DOI: 10.1007/s002510050218

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