Article
Impaired B cell maturation in mice lacking Bruton's tyrosine kinase (Btk) and CD40.
International immunology - 1 Mar 1997
Khan W N, Nilsson A, Mizoguchi E, Castigli E, Forsell J, Bhan A K, Geha R, Sideras P, Alt F W
Abstract excerpt
Mutations in Bruton's tyrosine kinase (Btk) gene, in mice, result in reduced numbers and responses of peripheral B cells. Surface Ig-mediated signaling is defective in Btk mutant B cells as they do not proliferate upon slg cross-linking and lack thymus-independent (TI) type II responses. Signals through sIg and CD40 play a critical role in B cell maturation. To investigate the consequences of the lack of both Btk...
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