Article
Impaired B cell maturation in mice lacking Bruton's tyrosine kinase (Btk) and CD40.
International immunology - 1 Mar 1997
Khan W N, Nilsson A, Mizoguchi E, Castigli E, Forsell J, Bhan A K, Geha R, Sideras P, Alt F W
Abstract excerpt
Mutations in Bruton's tyrosine kinase (Btk) gene, in mice, result in reduced numbers and responses of peripheral B cells. Surface Ig-mediated signaling is defective in Btk mutant B cells as they do not proliferate upon slg cross-linking and lack thymus-independent (TI) type II responses. Signals...
Topics
- Agammaglobulinaemia Tyrosine Kinase
- Agammaglobulinemia
- Animals
- B-Lymphocytes
- CD40 Antigens
- Cell Differentiation
- Female
- Genotype
- Hematopoiesis
- Immunization
- Immunologic Deficiency Syndromes
- Male
- Mice
- Mice, Knockout
- Protein-Tyrosine Kinases
- Receptors, Antigen, B-Cell
- Signal Transduction