Article
Genetic studies of the sulfonylurea receptor gene locus in NIDDM and in morbid obesity among French Caucasians.
Diabetes - 1 Apr 1997
Hani E H, Clément K, Velho G, Vionnet N, Hager J, Philippi A, Dina C, Inoue H, Permutt M A, Basdevant A, North M, Demenais F, Guy-Grand B, Froguel P
Abstract excerpt
The sulfonylurea receptor (SUR) is a key component in glucose-stimulated insulin secretion. Obesity and NIDDM are frequently associated and share some metabolic abnormalities, suggesting that they might also share some susceptibility genes. Thus, the SUR encoding gene is a plausible candidate for a primary pancreatic beta-cell defect and thus for hyperglycemia and weight gain. Through association and linkage...
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