Article
Role of the beta 3-adrenergic receptor locus in obesity and noninsulin-dependent diabetes among members of Caucasian families with a diabetic sibling pair.
The Journal of clinical endocrinology and metabolism - 1 Dec 1996
Elbein S C, Hoffman M, Barrett K, Wegner K, Miles C, Bachman K, Berkowitz D, Shuldiner A R, Leppert M F, Hasstedt S
Abstract excerpt
Obesity and insulin resistance are important risk factors for the development of noninsulin-dependent diabetes (NIDDM) and are prevalent among predisposed first degree relatives of diabetic individuals. Recent molecular screening and analysis of a common missense mutation of the beta 3-adrenergic...
Topics
- Adult
- Aged
- Chromosome Mapping
- Diabetes Mellitus, Type 2
- Female
- Genetic Linkage
- Humans
- Insulin Resistance
- Male
- Middle Aged
- Obesity
- Phenotype
- Receptors, Adrenergic, beta
- Receptors, Adrenergic, beta-3