Article
Variant in sulfonylurea receptor-1 gene is associated with high insulin concentrations in non-diabetic Mexican Americans: SUR-1 gene variant and hyperinsulinemia.
Human genetics - 1 Sept 1998
Goksel D L, Fischbach K, Duggirala R, Mitchell B D, Aguilar-Bryan L, Blangero J, Stern M P, O'Connell P
Abstract excerpt
The high-affinity sulfonylurea receptor (SUR1) gene regulates insulin secretion and may play a role in type 2 diabetes. A silent variant in exon 31 of SUR1 (AGG-->AGA) was detected by single-strand conformational polymorphism and genotypes were determined for 396 Mexican American subjects (289 no...
Topics
- ATP-Binding Cassette Transporters
- Adult
- Blood Glucose
- DNA Mutational Analysis
- Diabetes Mellitus, Type 2
- Female
- Genotype
- Humans
- Hyperinsulinism
- Insulin
- Male
- Membrane Proteins
- Polymorphism, Genetic
- Potassium Channels
- Potassium Channels, Inwardly Rectifying