Article
Linkage studies in NIDDM with markers near the sulphonylurea receptor gene.
Diabetologia - 1 Dec 1995
Stirling B, Cox N J, Bell G I, Hanis C L, Spielman R S, Concannon P
Abstract excerpt
The high affinity receptor for sulphonylureas, expressed on the beta cells of the pancreas, plays a crucial role in the control of insulin secretion. Mutations in the cytoplasmic domain of the sulphonylurea receptor (SUR) gene that disrupt the regulation of insulin secretion have been previously described. In the present study, the potential role of genetic variation in the SUR gene has been investigated in...
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