Article
p21WAF1/CIP1 and MDM2 expression in non-Hodgkin's lymphoma and their relationship to p53 status: a p53+, MDM2-, p21-immunophenotype associated with missense p53 mutations.
The Journal of pathology - 1 Jan 1997
Villuendas R, Pezzella F, Gatter K, Algara P, Sánchez-Beato M, Martínez P, Martínez J C, Muñoz K, García P, Sánchez L, Kocialkowsky S, Campo E, Orradre J L, Piris M A
Abstract excerpt
p53 is a tumour suppressor gene which is often found to be inactivated in most types of human cancer. p53 is a transcription factor, the inactivation of which may lead to significant variations in the levels of p53 downstream proteins, such as p21WAF1/CIP1 and MDM2. In view of the significance of p21WAF1/CIP1 and MDM2 as wild-type (wt) p53 targets, this study was undertaken to monitor the varying expression of...
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